- Case Report
- Testicular adrenal rest tumors in a patient with untreated congenital adrenal hyperplasia
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Hye Young Jin, Jin Ho Choi, Gu Hwan Kim, Chung Sik Lee, Han Wook Yoo
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Clin Exp Pediatr. 2011;54(3):137-140. Published online March 31, 2011
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Testicular adrenal rest tumors (TARTs) are considered to be formed from aberrant adrenal tissue that has become hyperplastic because of elevated adrenocorticotropic hormone (ACTH) in male patients with congenital adrenal hyperplasia (CAH). A 6-year-old boy presented with testicular enlargement and pubic hair. He was diagnosed with CAH complicated by precocious puberty. However, he was not followed-up. At the age of... |
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- Original Article
- Endocrine dysfunction after bone marrow transplantation during childhood and adolescence
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Hye Young Jin, Jin-Ho Choi, Ho-Joon Im, Jong-Jin Seo, Hyung-Nam Moon, Han-Wook Yoo
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Clin Exp Pediatr. 2010;53(3):420-427. Published online March 15, 2010
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Purpose : Several complications can occur in patients who received bone marrow transplantation (BMT) during childhood and adolescence. This study aims to investigate endocrine dysfunctions after BMT so that better care can be provided to care for long-term survivors of BMT.
Methods : One hundred patients (61 males, 39 females) were included in this study. Clinical parameters such as initial diagnosis,... |
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- Case Report
- Transient neonatal diabetes mellitus with macroglossia
diagnosed by methylation specific PCR (MS-PCR)
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Hye Young Jin, Jin-Ho Choi, Gu-Hwan Kim, Han-Wook Yoo
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Clin Exp Pediatr. 2010;53(3):432-436. Published online March 15, 2010
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Transient neonatal diabetes mellitus (TNDM) has been associated with paternal uniparental isodisomy of chromosome 6, paternally inherited duplication of 6q24, or a methylation defect at a CpG island of the ZAC or HYMAI gene. We experienced a case of TNDM in which the patient presented with hyperglycemia, macroglossia, and intrauterine growth retardation, caused by a paternally derived HYMAI. An 18-day-old... |
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- Hepatic glycogenosis in a patient with poorly controlled type 1 diabetes mellitus
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Hye Young Jin, Dae-Young Kang, Jin-Ho Choi
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Clin Exp Pediatr. 2009;52(11):1279-1282. Published online November 15, 2009
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Hepatomegaly and liver dysfunction might develop in patients with diabetes mellitus due to glycogen deposition or nonalcoholic steatohepatitis. We experienced a case of hepatic glycogenosis in a patient with type 1 diabetes mellitus who presented with recurrent hypoglycemia, suggesting impairment of glycogenolysis and gluconeogenesis. A 10-year-old girl with a 4-year history of type 1 diabetes mellitus was admitted because of... |
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- Original Article
- Clinical significance of loss of p16 protein by immunohistochemical
staining in acute lymphoblastic leukemia
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Hye Young Jin, Kyoung In Kang, Sun Young Kim, You Sook Youn, Joon Won Kang, Deog Yeon Jo, Kye Chul Kwon, Kyung Duk Park
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Clin Exp Pediatr. 2008;51(1):73-77. Published online January 15, 2008
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Purpose : p16 gene, mapped to the 9p21 chromosomal region, has emerged as a candidate tumor suppressor gene in human neoplasm. It is an inhibitor of cyclin-dependent kinase and inhibits Rb phosphorylation. In a variety of tumors including childhood acute lymphoblastic leukemia (ALL), deletion and/or mutation of the p16 gene has been found. Despite their high frequency, the prognostic importance... |
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